糜烂性脓疱性皮病读书报告

Erosivepustulardermatosis糜烂性脓疱性皮病

Clinicalfeatures临床特征Erosivepustulardermatosisofthescalpwasdescribedforthefirsttimeinasachronic,noninfectiousdermatosisprincipallyaffectingelderlywomen,andthereisafrequenthistoryoftraumatothescalp.Somecasesoutsidethescalphavebeenreported.Associationsdescribedincludecontusions,erosions,solarburns,herpeszoster,cochlearimplant,hairtransplant,radiation,syntheticfibreimplantations,cryotherapy,treatmentwithfluorouracil,tretinoin,followingtopicalmethylaminolaevulinatephotodynamictherapy,aftergefitinib,radiotherapy,andperinatalscalpinjury.Traumamayantedatethediseasebydaysoryears.

头皮糜烂性脓疱性皮病在年第一次被报导，该病是一种慢性非感染性皮肤病，特别好发于老年女性，通常有头皮反复外伤史。头皮外累及的病例也有报道。与该病发生相关的因素包括挫伤、腐蚀、太阳灼伤、带状疱疹、人工耳蜗移植、头发移植、放射、合成纤维植入物、冷冻治疗、氟尿嘧啶治疗、维甲酸、局部光动力治疗后、吉非替尼治疗后、放疗、围产期头皮损伤。创伤可能会发生在该病的几天或几年前。

Earlylesionsareasymptomaticandedematous,withwell-definedborderscharacterizedbyascalyscabthatuponwithdrawalleavesalesionwithpustules(Fig.22.).Latelesionsdevelopscarringalopecia.Theremaybesecondarybacterialorfungalcolonization.Ithasbeenassociatedwithbasalcellcarcinoma.

早期的皮损是无症状的水肿性，伴有明显的边界的鳞屑性结痂，脱落后遗留脓疱。晚期皮损形成瘢痕性脱发。可能会有继发性细菌或真菌定植。该病与基底细胞癌有关。

Pathogenesisandhistologicalfeatures发病机制和组织学特点

Thepathogenesisisunknown.Duetothehighincidenceinelderlypatientstherehasbeenspeculationastotherolethatchronicactinicdamage,immunosuppression,andautoimmunediseasemayhaveinthepathogenesisofthedisease.Laboratorydataandbacteriologicalandmycologicalinvestigationsareusuallynotdiagnostic.

发病机制尚不清楚。由于老年患者的高发病率，人们猜测慢性光化性损伤，免疫抑制和自身免疫疾病可能在发病机理中起作用。实验室数据以及细菌学、真菌学检测通常无诊断意义。

Thehistopathologicalpictureisnotspecific.Erosionofthesuperficialepidermiswithacanthosis,focalatrophy,parakeratosis,andsubcornealpustulesisseen.Inthedermisthereisamixedinflammatorycellinfiltrate







































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